The Laboratory Working Party

The Laboratory Working Party (LAB WP) is charged with designing studies to evaluate the variety of in-house PCR methodologies for testing whole blood, serum or plasma used by members of the group. It meets 2-3 a year plans and executes studies designed to identify the most important variables that influence the performance of PCR. The core group of 7 laboratories generates panels that are distributed to each of them and to a further 16 laboratories who form the extended group. The data generated is managed anonymously and analysed by the Statistical Working Party.

Juergen Loeffler (Chair)
Stephane Bretagne
Oliver Morton
Willem Melchers
Lewis White
Lena Klingspor, Stockholm
Katrien Lagrou, Leuven
Manuel Cuenca Estrella

Labs of the extended group:

  • Daniel Goldenberger, Basel
  • Elisabeth Johnson, Bristol
  • Martina Lengerova, Brno
  • Dieter Buchheidt, Heidelberg
  • Cornelia Lass-Florl, Innsbruck
  • Richard Hobson, Leeds
  • Johan Maertens, Leuven
  • Sendid Boualem, Lille
  • Chris Kibbler, London
  • Samir Agrawal, London
  • Malcolm Guiver, Manchester
  • Petr Hamal, Olomouc
  • Daniel Codl, Prague
  • Jose Palomares, Seville
  • Birgit Willinger, Vienna
  • Catriona Halliday, Westmead
  • Jacques Bille, Lausanne
  • Maurizio Sanguinetti, Rome
  • Markus Ruhnke, Berlin

Prof Juergen Loeffler, PhD

Secretary of the EAPCRI, Head of the Laboratory Working Party
Universitätsklinikum Würzburg
Medizinische Klinik II
Forschungslabore Haus C11
97070 Wuerzburg
Tel: +49 931 20136412

Dr. Loeffler is the head of the molecular biology laboratory of the Department of Internal Medicine.

For over 10 years, research in the group of Dr. Löffler is targeted towards immune recognition of A. fumigatus, genetic susceptibility to these fungi and molecular diagnosis of invasive fungal infections.

In addition, research is focused on identification, infection biology and immune recognition of cytomegalovirus and characterization of immune reconstitution after stem cell transplantation.

Prof Stéphane Bretagne, PhD, MD

Member of the Laboratory Working Party of the EAPCRI
University Paris-Est
Faculty of Medicine
8 ave Gl Sarrail
94010 Créteil
Telephone: +33 49813601

Pr. Bretagne is the head of the parasitology and mycology laboratories of the Medicine Faculty and Henri Mondor hospital.

For over 15 years, both the hospital and the faculty groups of Pr Bretagne develop diagnostic PCR assays for opportunistic diseases. The laboratory is also interested in genotyping of fungi to draw correlations between phenotypes and genotypes. The academic research is focused on the effects of Aspergillus spp. on the respiratory airway epithelium.

For 10 years the laboratory has been involved in several clinical studies dealing with invasive fungal infections in collaboration with the hematological department of Henri Mondor hospital.

Dr C. Oliver Morton, PhD

Lecturer in Medical Microbiology
School of Science and Health
University of Western Sydney
B21. L1. R29
Campbelltown Campus
NSW, Australia
Phone: +61 2 4620 3446

Dr Morton is a post doctoral research fellow in the Department of Clinical Microbiology, Trinity College Dublin.For the past four years he has been working in an Aspergillus Research Group led by Prof. Thomas Rogers. The work of this group has focused on PCR-based detection of fungal nucleic acids in patient samples and the identification of pathogenic fungi.Other research in the group has examined the interaction between Aspergillusand immune cells to gain a more detailed understanding of the host-pathogen interactome.

Dr Willem JG Melchers, PhD


Radboud University Nijmegen Medical Centre
Dept. Medical Microbiology
P.O. Box 9101
6500HB Nijmegen
The Netherlands
Tel: +31-24-614356

Willem JG Melchers is associate professor in Molecular Microbiology. He is also head of the section Molecular Diagnostics of the Department of Medical Microbiology.

Dr. P. Lewis White, PhD


Laboratory Working Party, Panel development and distribution
NPHS Microbiology Cardiff
University Hospital of Wales
Heath Park
Cardiff. CF14 4XN
Tel: +44 (0)29 2074 6581

Dr. White is the lead clinical scientist for the regional mycology laboratory, the Wales Centre for Mycobacteria and deputy head of molecular diagnostics for NPHS microbiology Cardiff.For the last 10 years his research has focused on the molecular diagnosis of invasive fungal infections, with an emphasis on Aspergillus and Candida and incorporating these tests in to a clinical setting.Additional, research has focused on antifungal susceptibility, molecular detection and identification of mycobacteria and the molecular genotyping of Mycobacterium tuberculosis.

Dr. Lena Klingspor, Md, PhD

Member of the EAPCRI laboratory Working Party and in the steering commitée of the Clinical working
Karolinska Institutet
Department of Laboratory Medicin
Division of Clinical Microbiology, F 72
Karolinska University Hospital
SE-141 86 Stockholm
Tel: +46 8 5858 7839
Mobile: 0704-84 1939
Fax: + 46 8 5858 1125

Ass. Prof. Lena Klingspor  is the medical Head of the Mycology Unit at Karolinska University Hospital in Huddinge and Solna and also works as a consultant Senior Physician in Paediatrics.

Research has been focused on the field of Medical Mycology concerning: Epidemiology, Clinic, risk factors, diagnosis and treatment in children and adults. In diagnostics: To develop and to evaluate different diagnostic tests in patients.

Dr Katrien Lagrou, PhD

Member of the EAPCRI Laboratory Working Party
Laboratorium Klinische Bacteriologie en Mycologie
UZ Herestraat 49 – bus 7003
3000 Leuven
Tel:+32 16 3 47098

Dr. Lagrou is head of the Molecular Diagnostic Laboratory at the University Hospital of Leuven, Belgium and the Belgian National Reference Center for Mycosis.

She is Professor at the faculty of Medicine of the Catholic University of Leuven. Katrien Lagrou’ s main interest is the diagnosis of fungal and viral infections in severely immunocompromised patients with a focus on invasive pulmonary aspergillosis and Candida albicans biofilms.

She is General Secretary of the European Confederation of Medical Mycology.

Dr. Manuel Cuenca-Estrella, PhD

Member of the EAPCRI Laboratory Working Party
Servicio de Micología
Centro Nacional de Microbiología
Instituto de Salud Carlos III
Ctra. Majadahonda-Pozuelo Km 2
Majadahonda, Madrid 28220
Phone: +34 91 8223726

Dr. Cuenca-Estrella is the Director of the Spanish Reference Laboratory of Medical Mycology where run a variety of research projects and scientific activities focused on fungal infections afflicting humans, early diagnosis of invasive fungal infections, standardization of antifungal susceptibility testing, resistance mechanisms, and taxonomy of fungal species.

Among others, Dr. Cuenca-Estrella is a member of several international associations and is a regular speaker at international meetings on aspects of fungal infections. He is the Chairman of European Fungal Infections Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG-ESCMID).